Renin, additionally called angiotensinogenase, is an enzyme associated in the renin–angiotensin aldosterone device (RAAS), which regulates the body’s water balance and blood push level. The system regulates the extracellular volume in the blood plasma, lymph and also interstitial fluid, and also controlling constriction the the arteries and also blood vessels.

You are watching: The kidneys are stimulated to produce renin


Renin was very first discovered through a physiology researcher Robert Tigerstedt and Per Bergman native the Karolinska academy in Stockholm. Castle described and named the enzyme in 1898. The renin precursor protein is comprised of 406 amino acids and also possesses a pre- and a pro-segment consisted of of 20 and also 46 amino acids, respectively. The mature type of the enzyme has 340 amino acids and also has a fixed of 37 kDa.

This peptide hormone is secreted through the kidney from committed cells dubbed granular cells found in the juxtaglomerular apparatus. The secretion of renin is stimulated by the following three factors:

When a loss in arterial blood pressure is detected by press sensitive receptor (baroreceptors) in the arterial vessels.When a diminish in salt chloride (salt) is detected in the kidney by the macula densa in the juxtaglomerular apparatus.When sympathetic concerned system task is detected with beta1 adrenergic receptors.

There space two cellular pathways associated in the cheap of renin:

Prorenin is secreted through a constitutive pathwayRenin is secreted v a regulated pathway

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last Updated: Jun 26, 2019


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Written by

Dr. Ananya Mandal

Dr. Ananya Mandal is a physician by profession, lecturer through vocation and a clinical writer through passion. She dedicated in Clinical Pharmacology after she bachelor's (MBBS). Because that her, health communication is not just writing complex reviews for professionals however making medical knowledge understandable and easily accessible to the general public together well.


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