Trifluoroethanol serves together a solvent and also a raw product in necessary chemistry and biology. TFE is a solvent of choice for hydrogen peroxide-mediated oxidations the sulfides. Trifluoroethanol acts together a protein denaturant. The is offered in the to produce of particular pharmaceuticals and drug substances. The drug fluromer, which is 2,2,2-trifluoro-1-vinyloxyethane, is the vinyl ether that trifluorethanol. That is an effective solvent because that peptides and proteins, and used for NMR-based protein folding studies, and in the produce of nylon. As a resource of the trifluoromethyl group, that is to work in several organic reactions, for instance in Still-Gennari change of Horner-Wadsworth-Emmons reaction (HWE) reaction.
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valuable ionizing solvent, see: Tetrahedron Lett., 2335 (1974), and references therein. Great solvent for oligopeptides with potential as a cosolvent along with proton acceptors such together DMF for peptide coupling reactions: Tetrahedron Lett., 33, 7007 (1992). To compare 1,1,1,3,3,3-Hexafluoro-2-propanol, A12747.
reliable solvent because that uncatalyzed epoxidations that alkenes v hydrogen peroxide (caution! 60%): Synlett, 248 (2001). Because that a testimonial of fluorinated alcohols as solvents for selective and also clean reactions, see: Synlett, 18 (2004).
Trifluoroethyl esters have likewise found usage as active esters in peptide coupling; see, for example: J. Chem. Soc., Perkin 1, 2867 (1996).
Reacts v triphenylphosphine dibromide to give the bis(trifluoroethoxy)phosphorane, which converts alcohols come trifluoroethyl ethers, carboxylic acids to trifluoroethyl esters and also aldehydes come bis(trifluoroethyl) acetals: J. Org. Chem., 45, 5052 (1980).
The stereodirecting effect of the MEM team (see 2-Methoxyethoxymethyl chloride, L01050) has been exploited through Percy et al in the development of a new fluorine-containing acyl anion equivalent: Tetrahedron, 51, 9201 (1995):
Claisen or Wittig rearrangements of the derived difluoroallyl alcohols deserve to be supplied in paths to molecules containing a CF2 group: Tetrahedron, 51, 11327 (1995); J. Org. Chem., 61, 166 (1996), or to monofluorinated vinylic compounds: Tetrahedron Lett., 37, 5183 (1996).
Bava, Y. B.; Martínez, Y. B.; Betancourt, A. M.; Erben, M. F.; Filho, R. L. C.; Védova, C. O. D.; Romano, R. M. Ionic Fragmentation instrument of 2, 2, 2-Trifluoroethanol following Excitation with Synchrotron Radiation. ChemPhysChem 2015, 16 (2), 322-330.
Scodeller, I.; Salvini, A.; Manca, G.; Ienco, A.; Luconi, L.; Oberhauser, W. 2,2,2-Trifluoroethanol-assisted imine hydrogenation by a Ru-monohydride. Inorg. Chim. Acta 2015, 431, 242-247.
GHS Hazard and Precautionary Statements
Flammable liquid and also vapour. Toxic if swallowed. Toxicity if inhaled. Reasons serious eye damage. May damage fertility. May reason damage to organs through an extensive or repetitive exposure.
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Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Wear security gloves/protective clothing/eye protection/face protection. IF on SKIN: Wash through plenty the soap and also water. IF INHALED: remove to new air and also keep at rest in a place comfortable because that breathing. IF IN EYES: rinse cautiously with water for several minutes. Remove contact lenses, if present and easy come do. Continue rinsing. Immediately call a POISON facility or doctor/physician.